• Zhen Kun Xiao, Bing Wang, JianHua Liu, YiBo Yang, Niu Jie, XingYu Mao, XinYuan Gong, AiHua Liu, and Yong Hong Duan.
• Hengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease, Department of Neurosurgery, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
• World Neurosurg. 2024 Sep 27.

BackgroundAneurysmal subarachnoid hemorrhage (aSAH) is a common neurosurgical disorder with high morbidity and poor prognosis, and the associated delayed cerebral ischemia (DCI) is a key factor contributing to poor prognosis. Despite extensive research on the risk factors associated with DCI development, the evidence remains conflicting. Therefore, this meta-analysis of case-control studies aimed to investigate the risk factors for DCI occurrence during hospitalization in patients with aSAH.MethodsWe systematically searched PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials for eligible studies published before November 20, 2023. Two independent reviewers extracted relevant data from the included studies using a pre-established data extraction form. The primary outcome was DCI occurrence during hospitalization in patients with aSAH.ResultsA total of 42 studies involving 21,726 patients with aSAH were included. The pooled meta-analysis showed that female sex; Hunt-Hess, modified Fisher, and World Federation of Neurosurgical Societies (WFNS) scale scores of 4-5, 3-4, and 4-5, respectively; vasospasm; combined intraventricular hemorrhage (IVH); pre-existing hypertension; hydrocephalus; intracranial infections (ICI); and high white blood cell (WBC) count on admission were independent risk factors for the development of postoperative DCIs in patients with aSAH.ConclusionsPatients with aSAH who have a Hunt-Hess scale score ≥4, a modified Fisher scale score ≥3, a WFNS scale score ≥4, IVH, pre-existing hypertension, cerebral vasospasm, a high WBC count on admission, ICI, and female sex are at high risk of DCI and hence should be carefully monitored in the intensive care unit.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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