• Ali Selcuk Yeniocak, Can Tercan, Emrah Dagdeviren, Onur Arabaci, and Emine Elif Genc Arabaci.
• From the Department of Obstetrics and Gynecology, T.C. Sağlık Bakanlığı Başakşehir Çam ve Sakura Şehir Hastanesi, Basaksehir, Istanbul, Turkey.
• Ann Saudi Med. 2024 Sep 1; 44 (5): 306318306-318.

BackgroundPregnant individuals have faced unique challenges during the COVID-19 pandemic, necessitating a closer examination of maternal and fetal health outcomes.ObjectivesInvestigate the morbidity and mortality associated with SARS-CoV-2 infection among pregnant individuals, considering vaccination status and variant strains.DesignRetrospective cohort.SettingTertiary state hospital.Patients And MethodsPatients who underwent cesarean sections were categorized into three periods: pre-vaccination (before 31 August 2021), early post-vaccination (from September 2021), and late post-vaccination (aligned with 70% immunization coverage by 2 September 2021). Data collected included demographic information (age, gravidity, parity count, gestational age, newborn APGAR scores), cesarean section indications, chronic diseases, vaccination status, vaccine type and doses, SARS-CoV-2 variant status, ICU admission, and mortality due to COVID-19.Main Outcome MeasuresICU admission and mortality rates, focusing on the impact of SARS-CoV-2 infection and vaccination status.Sample Size297 COVID PCR-positive symptomatic patients who underwent cesarean sections.ResultsIn the pre-vaccination group, there were 13 mortalities (8.1%) compared to 9 (6.6%) post-vaccination (P=.610). Maternal ARDS was seen in 46.2% of pre-vaccination mortalities versus 11.1% post-vaccination (P=.045). COVID-19 delta variant patients had higher ICU admission (80%) and mortality rates (40%). Rates of COVID-19 PCR-positive cesarean sections, ICU admissions, and mortality declined significantly in early (P=.021, P=.004, P=.009), respectively and late post-vaccination periods (P<.001, P<.001, P=.0019), respectively. Vaccinated patients had no ICU admissions or mortality.ConclusionsVaccination against COVID-19 is crucial for pregnant individuals as it significantly reduces the risk of severe illness. While vaccines offer substantial protection, the pandemic's acute phase might be waning, yet COVID-19 remains a global threat, particularly in regions with limited vaccine access. Continued vigilance and proactive measures are essential to mitigate ongoing risks and the emergence of new variant strains.LimitationsRetrospective observational design and the single-center setting, which may affect the generalizability of the findings.

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