• Chien-Ting Sun, Yi-Shan Yang, Chen-Ling Lan, Huy Minh Tran, Tuan Anh Pham, Yung-Hsiao Chiang, Chien-Min Lin, Yu-Kai Su, Yi-Chen Hsieh, and Jiann-Her Lin.
• Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan.
• Eur Spine J. 2024 Dec 1; 33 (12): 451345204513-4520.

PurposeTo compare vertebroplasty (VP) and kyphoplasty (KP) with a titanium implantable vertebral augmentation device (TIVAD) in symptomatic subsequent vertebral compression fracture (SVCF) incidence among osteoporotic vertebral compression fracture (OVCF) patients stratified by age and sex.MethodsThis retrospective cohort study involved OVCF patients aged ≥ 50, who underwent KP with TIVAD or VP in our hospital from 2014 to 2019. Subgroup analysis was conducted to evaluate the efficacy of KP with TIVAD and VP in patients stratified by age and sex.ResultsThe study included 472 patients (VP group: 303; TIVAD group: 169). SVCF incidence rates were 15.2% for VP group and 14.8% for TIVAD group (P = 0.87). In subgroup analysis, TIVAD group showed significantly lower SVCF incidence than VP group in women aged 50-70 (2.1% vs 14.3%; P = 0.03) and had significantly higher SVCF incidence than VP group in women aged > 70 (24.2% vs 13.1%; P = 0.02). In men, adjacent SVCF incidence was significantly lower in TIVAD group than VP group (0% vs 14.1%; P = 0.03).ConclusionCompared to VP, TIVAD is associated with lower symptomatic SVCF rate in men and younger women aged 50-70 but not in older women aged > 70. Age and gender may influence SVCF incidence.Level Of EvidenceDiagnostic: individual cross-sectional studies with consistently applied reference standard and blinding.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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