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- Peter Yi and Peter Pryzbylkowski.
- Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
- Pain Med. 2015 Oct 1; 16 Suppl 1: S32-6.
ObjectiveTo discuss the phenomenon of opioid induced hyperalgesia (OIH) and investigate the data and clinical recommendations available on this topic.DesignA literature search on the topic of OIH was performed. Relevant studies pertaining to OIH were included in this review.ResultsExisting studies and reviews on the pathophysiology, diagnosis, and clinical management of OIH are discussed with updated data and literature references.ConclusionAs more opioids are prescribed, especially to treat chronic nonmalignant pain, OIH becomes more of a relevant and significant issue. Although the exact mechanisms of OIH are not clearly understood further research is required to broaden and develop our knowledge of this topic.Wiley Periodicals, Inc.
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