• Lintao Dan, Ying Xie, Tian Fu, Yuhao Sun, Xuejie Chen, Xiaoyan Wang, Chenkai Wu, Jie Chen, and Xue Li.
• Department of Gastroenterology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, Hunan 410013, P.R. China; Department of Big Data in Health Science School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
• Am. J. Med. 2024 Oct 4.

BackgroundCross-sectional evidence suggests a higher burden of chronic respiratory diseases in people with inflammatory bowel disease, but there is a lack of prospective evidence to clarify the direction of their associations.AimTo investigate the association of inflammatory bowel disease with the risk of two major chronic respiratory diseases, chronic obstructive pulmonary disease and asthma.MethodsWe included 430,414 participants from UK Biobank and followed them from recruitment (2006-2010) to 2021. Chronic obstructive pulmonary disease and asthma cases were obtained from inpatient data and death register. Using Cox proportional hazards models, we estimated the multivariable-adjusted hazard ratios (HR) of developing chronic obstructive pulmonary disease and asthma in participants with inflammatory bowel disease compared with inflammatory bowel disease-free groups. We also investigated the association among Crohn's disease and ulcerative colitis with the risk of chronic obstructive pulmonary disease and asthma.ResultsOver a median follow-up of 11.9 years, there were 11,196 incident chronic obstructive pulmonary disease and 9831 asthma cases. The adjusted HRs of developing chronic obstructive pulmonary disease (HR=1.54, 95% CI: 1.33-1.79) and asthma (HR=1.52, 95% CI: 1.29-1.79) were higher for those with inflammatory bowel disease when compared with inflammatory bowel disease-free participants. Participants with Crohn's disease and ulcerative colitis were also found to have a higher risk of chronic obstructive pulmonary disease (Crohn's disease: HR=1.71; 95% CI: 1.36-2.15; ulcerative colitis: HR=1.45; 95% CI: 1.20-1.75) and asthma (Crohn's disease: HR=1.73; 95%CI: 1.33-2.25; ulcerative colitis: HR=1.41; 95%CI: 1.15-1.73) when compared with those free of inflammatory bowel disease.ConclusionsThis study suggested that individuals with inflammatory bowel disease have a higher risk of developing chronic obstructive pulmonary disease and asthma, highlighting the importance of preventing chronic respiratory diseases among inflammatory bowel disease patients.Copyright © 2024. Published by Elsevier Inc.

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