• Internal medicine · Oct 2024

    Glut-1-Negative Choroidal Malignant Melanoma with Liver Metastasis Recurrence 12 Years after Surgery without FDG Accumulation in a Recurrent Lesion on FDG-PET/CT: a Case Report.

    • Toyoki Shimamoto, Hironori Ochi, Cao Fang, Michiko Amano, Takaaki Tanaka, Nobuaki Azemoto, Toshie Mashiba, Koichi Kimura, Ryosuke Minagawa, Yumi Ooshiro, Toshio Kodama, and Tomoyuki Yokota.
    • Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan.
    • Intern. Med. 2024 Oct 4.

    AbstractChoroidal malignant melanoma is a rare malignant tumor that develops in adult eyeballs. It causes early lymph node and distant metastasis. Fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (CT) is widely used for screening malignant melanoma metastases. We encountered a 58-year-old man with choroidal malignant melanoma in whom liver metastasis recurred 12 years after surgery, without any observable FDG accumulation. Immunostaining revealed the absence of glucose transporter type 1 (GLUT-1) expression, crucial for intracellular FDG uptake. The lack of FDG accumulation in the lesion could be attributed to the diminished cellular FDG uptake due to the absence of GLUT-1 expression.

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