• Faxing Wang, Jimin Wu, Yini Wu, Xin Han, Hong Dai, and Qin Chen.
• Department of Anesthesiology, Lishui People's Hospital, Lishui Hospital of Wenzhou Medical University, No. 1188 Liyang Street, Lishui, Zhejiang, 323000, People's Republic of China.
• Arch Orthop Trauma Surg. 2024 Oct 7.

IntroductionTo comprehensively compare the effect of different peripheral nerve blocks for patients undergoing total knee arthroplasty (TKA).Materials And MethodsPubMed, Embase, Cochrane Library, and Web of Science were comprehensively searched. The outcomes included postoperative pain, postoperative function, adverse events, oral morphine equivalent (OME), and perioperative indicators. Network plots, forest plots, league tables and rank probabilities were drawn for all outcomes.ResultsTotally 30 studies were included. For postoperative pain, continuous adductor canal block (cACB) + genicular nerve block (GNB) was most likely to be the most effective block regarding rest pain score at 24 h; cACB + GNB was most likely to result in the lowest rest pain score at 48 h; patients undergoing cACB + infiltration between the popliteal artery and the capsule of the knee (IPACK) + GNB was most likely to have the lowest motion pain score at 24 h; patients undergoing cACB + GNB was most likely to have the lowest motion pain score at 48 h. For postoperative function, patients undergoing cACB + IPACK + GNB had the highest likelihood to exhibit the shortest time in Timed Up and Go test (TUG); cACB + tibial nerve block (TNB) was most likely to be the most effective block in terms of range of motion (ROM); cACB + IPACK was most likely to be the optimal block concerning the ambulation distance.ConclusioncACB combined with IPACK/GNB may be the most favorable block after TKA, continuous blocks may be better than single-shot blocks, and combined blocks may be better than separate blocks.© 2024. The Author(s).

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