• Guang-Hua Deng.
• Ya'an Hospital of Traditional Chinese Medicine.
• Medicine (Baltimore). 2024 Sep 20; 103 (38): e39783e39783.

ObjectiveCurrently, the number of patients with spinal stenosis is increasing, and most of the patients are found to have a history of smoking in the clinic. In this study, we used the Mendelian randomization (MR) method to investigate the causal relationship between smoking and spinal stenosis.MethodsGenetic loci independently associated with smoking and spinal stenosis in people of European ancestry were selected as instrumental variables using pooled data from large-scale genome-wide association studies (GWAS). Three MR analyses, MR-Egger, Weighted median and inverse variance weighting (IVW), were used to investigate the causal relationship between smoking and spinal stenosis. The results were tested for robustness by heterogeneity and multiplicity tests, and sensitivity analyses were performed using the "leave-one-out" method.ResultsThe IVW results showed an OR (95% CI) of 2.40 (0.31-18.71), P = .403, indicating that there was no causal relationship between smoking and spinal stenosis. And no heterogeneity and multiplicity were found by the test and sensitivity analysis also showed robust results.ConclusionIn this study, genetic data were analyzed and explored using 2-sample MR analysis, and the results showed that there is a causal relationship between smoking and the occurrence of spinal stenosis, and more studies need to be included.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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