• Jing Fu, Zhiqiang Nie, Yanfeng Zhang, Min Tang, and Jianguo Guo.
• Department of Stomatology, Hangzhou Xixi Hospital, Hangzhou, China.
• Medicine (Baltimore). 2024 Sep 20; 103 (38): e39353e39353.

BackgroundThe trigeminal neuralgia (TN) is characterized by a unilateral, episodic, electric shock-like pain in the distribution of the trigeminal nerve. Both drug therapy and radiofrequency thermocoagulation (RT) are used to treat TN.ObjectiveTo compare the efficacy and safety of RT and drug therapy in patients with TN.MethodsBetween October 2020 and December 2022, 62 patients with TN were allocated to undergo TN treatment (group A) or drug therapy (group B). In group A, 30 patients received RT treatment, whereas 32 patients in group B receive drug treatment. Pain relief, clinical outcomes, and adverse events in both groups were evaluated.ResultsAnd significantly greater reduction in Visual Analogue Scale scores was noted in group A than in group B in the initial 2-week period (P < .05). The excellent rate was 93.3% (28/30) in group A, whereas it was 68.8% (22/32) in group B during the initial 2-week period (P < .05). A total of 62 patients were followed up at least 12 months, with a mean follow-up time of 14.5 months. But there were no statistically significant differences between the 2 groups at the final follow-up. A total of 24 patients had facial numbness in group A. In contrast, ten patients in group B complained of discomfort including sedation, dizziness, nausea, vomiting. During the follow-up period, 4 patients in group A and 6 patients in group B experienced recurrent pain.ConclusionRT is a safety and effective treatment for patients with classic TN, providing more benefits of quicker pain relief and higher patient's satisfaction, compared with traditional drug therapy.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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