• Firas S Azzeh, Waad W Kamfar, Mazen M Ghaith, Radi T Alsafi, Ghalia Shamlan, Mai A Ghabashi, Wesam F Farrash, Reema A Alyamani, Awfa Y Alazzeh, Sarah O Alkholy, El-Sayed H Bakr, Alaa H Qadhi, and Ahmad F Arbaeen.
• Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
• Medicine (Baltimore). 2024 Sep 20; 103 (38): e39657e39657.

AbstractMelatonin (MLT) is crucial in controlling human sleep-wake patterns. While it has long been recognized for regulating circadian rhythms, its demonstrated efficacy in managing various diseases has recently gained considerable attention. This review discusses MLT's potential preventative and therapeutic effects on various diseases. Several studies have focused on examining the molecular mechanisms through which MLT brings about its protective or therapeutic effects on various diseases, including cancer, obesity, coronavirus, and cardiovascular diseases. Numerous preventative and therapeutic applications of MLT have been proposed, resulting from its ability to function as an antioxidant, anti-cancer, anti-inflammatory, and immune-regulating agent. There is a need for further research to determine MLT's long-term effects on antioxidant defense systems, its preventative and therapeutic benefits, and its molecular basis.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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