• Linying Wang, Lvjun Zhang, Chiqing Ying, Xuehang Jin, Mingliang Ying, Hui Chen, and Dan Zhu.
• Department of Respiration and Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China.
• Medicine (Baltimore). 2024 Sep 27; 103 (39): e39807e39807.

RationaleCryptogenic organizing pneumonia (COP) is a type of pneumonia with unknown cause, presenting with symptoms like dyspnea, fever, and cough. Solanine poisoning can cause symptoms like increased heart rate, rapid breathing, sore throat, diarrhea, vomiting, and fever, but there are no known cases of it causing COP.Patient ConcernsA 43-year-old man had a dry cough, worse at night, with phlegm and chest tightness after eating sprouted potatoes. No history of surgeries or family medical issues.DiagnosisLaboratory tests and metagenomic next-generation sequencing of bronchoalveolar lavage fluid from the bilateral lower lobes did not yield a definitive pathogen. Further evaluation included testing for vasculitis-associated antibodies and rheumatologic immune markers for myositis spectra to rule out connective tissue disease-associated interstitial lung disease as the etiology of organizing pneumonia. As a result, the final diagnosis was determined to be COP.InterventionsThe patient received glucocorticoid therapy and oxygen therapy, and responded well to the treatment.OutcomesOn the 10th day of hospitalization, the patient was discharged with success. A follow-up chest CT conducted over a month later revealed that the lesions in both lungs had essentially resolved, with only minor residual fibrotic changes present.LessonsRegularly monitoring disease progression is crucial for patients with solanine poisoning who have pulmonary symptoms. Promptly conducting chest CT scans and bronchoscopy is advised to check for any infections. It is also important to rule out pneumonia related to connective tissue disease-associated interstitial lung disease and provide appropriate treatment promptly.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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