• Jiaqi Nie, Xue Qin, Xiang Tao, and Jin Huang.
• Clinical Laboratory Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
• Medicine (Baltimore). 2024 Sep 27; 103 (39): e39622e39622.

AbstractMolecular structure and cellular distribution of lymphocyte activation gene-3 (LAG-3) have been studied extensively since 1990. However, several unresolved questions remain. It is well-established that LAG-3 plays a significant role in maintaining immune homeostasis. The presence of deficiencies in LAG-3 has been observed to be linked with autoimmune disorders, whereas the excessive expression of LAG-3 within the tumor microenvironment hinders immune responses, particularly those mediated by lymphocytes, thereby facilitating immune evasion. Consequently, investigations into these 2 aspects have become a prominent focus in both fundamental and clinical research. The objective of this review is to examine the functions and molecular characteristics of LAG-3, as well as its current clinical applications in the context of tumor immune escape and autoimmune disease. The ultimate aim is to explore and propose novel immune therapy approach.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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