• QingHua Zou, ZhaoChuan Yin, LiLi Ding, Jiang Ruan, GuoYun Zhao, XiaoQiong Wang, YiJun Li, QingWen Xu, XueJing Gong, WenShuo Liu, KaiWen Shi, and WeiMing Li.
• Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
• Medicine (Baltimore). 2024 Sep 27; 103 (39): e39844e39844.

BackgroundThe clinical benefit of preoperative oral nutritional supplements (ONS) in patients undergoing surgery for gastrointestinal cancer remains controversial.ObjectiveTo evaluate the effect of preoperative ONS on postoperative clinical outcomes in patients with gastrointestinal cancer.MethodsWe searched PubMed, EMBASE, Web of Science, Cochrane Library, Scopus, and the Chinese National Knowledge Infrastructure databases for randomized controlled trials evaluating preoperative ONS in patients undergoing surgery for gastrointestinal cancer from inception until April 2024. Two researchers independently assessed the quality of the included literature and performed statistical analyses using Review Manager 5.4 software.ResultsA total of 12 eligible studies with 1201 patients (600 ONS group and 601 control group) were included in this meta-analysis. Compared with a normal diet, preoperative ONS effectively reduced infectious complications (odds ratio = 0.63; 95% confidence interval [CI], 0.40-0.98; P = .04), white blood cell count (mean difference [MD] = -0.66; 95% CI, -1.04 to -0.28; P = .0007), C-reactive protein (MD = -0.26; 95% CI, -0.33 to -0.19; P < .00001), and markedly improved albumin levels (MD = 1.71; 95% CI, 0.97-2.46; P < .00001), prealbumin (MD = 24.80; 95% CI, 1.72-47.88; P = .04), immunoglobulin G (MD = 0.86; 95% CI, 0.44-1.28; P < .00001), CD4 T lymphocyte cells (MD = 3.06; 95% CI, 2.21-3.92; P < .00001), and CD4 T lymphocyte cells/CD8 T lymphocyte cells (MD = 0.33; 95% CI, 0.10-0.56; P = .004). However, there were no significant differences between the 2 groups in terms of noninfectious complications (odds ratio = 0.77; 95% CI, 0.39-1.53; P = .46), immunoglobulin A (MD = -0.21; 95% CI, -0.44 to 0.02; P = .08) or length of hospital stay (MD = -0.04; 95% CI, -0.71 to 0.64; P = .92).ConclusionPreoperative ONS may effectively reduce postoperative infectious complications, improve postoperative nutritional status and immune function, and relieve the inflammatory response in gastrointestinal cancer patients. Therefore, we recommend that preoperative nutrition could be optimized with ONS in patients undergoing gastrointestinal cancer surgery.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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