• Fatih Dal, Hasan Ökmen, Kivilcim Ulusan, Battal HavareSemihaSDepartment of Medical Pathology, Health Sciences University Turkish Ministry of Health İstanbul Research and Training Hospital, İstanbul, Turkey., and Serkan Sari.
• Department of General Surgery, Health Sciences University Turkish Ministry of Health İstanbul Research and Training Hospital, İstanbul, Turkey.
• Medicine (Baltimore). 2024 Sep 27; 103 (39): e39860e39860.

AbstractIn this study, we aimed to investigate the prognostic effect of the classifications made according to the stage of the largest lesion diameter (T-max stage) and of the sum of the longest diameters of the lesions (T-sum stage), the largest area stage (A-max stage), the sum of the largest areas (A-sum stage), the highest volume stage (V-max stage), the sum of the highest volume (V-sum stage) on disease-free survival, and overall survival (OS) in multifocal/multicentric breast cancers (MMBCs) and unifocal breast cancers (UBCs). The study included a total of 769 patients either with MMBC (n = 128) or UBC (n = 641) who underwent surgery between 2006 and 2015. In the analysis, the median age of 769 patients was 53.0 (20.0-94.0) years, and 16.6% of these 769 patients were MMBC and 83.4% were UBC. In multivariate analysis, lymphovascular invasion (LVİ), estrogen receptor, and nodal status were common independent prognostic factors, whereas T-max stage [(HR: 1.17) (CI 95%: 1.03-1.33) (P = .018)] was a prognostic factor for OS. In multivariate analysis, the T-max stage is an independent risk factor for OS. Therefore, T-max should be continued to be used for measurement and T-stage should be used for classification in MMBCs/UBCs.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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