• J. Cardiothorac. Vasc. Anesth. · Sep 2024

    Effect of Deep Hypothermia (18°C) on Dioxygen Metabolism During Pulmonary Thromboendarterectomy Surgery.

    • Sylvain Diop, Elie Fadel, Pauline Valentini, Alexandre Thepaut, Thibaut Genty, Iolanda Ion, Filip De Somer, and Jacques Thes.
    • Department of Anesthesiology, Marie Lannelongue Hospital, Paris Saint Joseph Hospital, Le Plessis Robinson, France; Cardiothoracic Intensive Care Unit, Marie Lannelongue Hospital, Paris Saint Joseph Hospital, Le Plessis Robinson, France. Electronic address: menes.diop@gmail.com.
    • J. Cardiothorac. Vasc. Anesth. 2024 Sep 19.

    ObjectivesThe aim of this physiological pilot study was to investigate the effect of deep hypothermia on oxygen extraction (OE) and consumption (VO2) in normothermic conditions (36-37°C), and at different stages of cooling: 30°C, 25°C, and 18°C.DesignFor 3 months, a prospective study was conducted on patients who underwent pulmonary thromboendarterectomy.SettingsThis was a single-center study done in a university teaching hospital.ParticipantsPatients who underwent pulmonary thromboendarterectomy during the inclusion period.InterventionsHemodynamic and biological data were recorded from arterial and venous blood gas samples withdrawn first at normothermia, then at 30°C, 25°C, and 18°C.Measurements And Main Results24 patients were included in the final analysis. Indexed VO2 decreased from 65.9 mL to 25.1 mL of O2/min/m2 between 36°C and 18°C (p < 0.001). The OE decreased from 18% to 9% between 36°C and 18°C (p < 0.001). At normal temperature and 18°C, the median venoarterial difference of O2 bound to hemoglobin was 2.22 [1.68-2.58] and 0.03 mL [0.01-0.07] of O2/100 mL of blood, respectively (p < 0.001). Whereas the median venoarterial differences in dissolved O2 were 0.78 [0.66-0.92] and 1.09 mL [1.03-1.32] of O2/100 mL of blood, respectively (p = 0.0013).ConclusionThere were VO2 and OE decreases of more than half their baseline values at 18°C. Given that metabolic needs are essentially supplied by dissolved O2 during cooling from 30°C to 18°C, the authors suggest that PaO2 should be increased during the period of cooling and/or deep hypothermia to prevent hypoxia.Copyright © 2024 Elsevier Inc. All rights reserved.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…