• Tao He, Xue Li, Chun-Juan Liao, Xing-Yu Feng, and Xiang-Yu Guo.
• The State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
• J Chin Med Assoc. 2024 Oct 11.

BackgroundTo assess the association between periodontal disease (PD) and the prognosis of chronic kidney disease (CKD).MethodsA systematic literature search was conducted using PubMed, Embase, and Cochrane Library to identify eligible cohort studies until April 2023. Relative risk (RR) with a 95% confidence interval (CI) was used to evaluate the strength of the relationship between PD and CKD prognosis using the random-effects model.Results10 cohort studies involving 10,144 patients with CKD were selected for the meta-analysis. The summary results indicated that PD was associated with an increased risk of all-cause mortality in patients with CKD (RR:1.32; 95%CI:1.10-1.59; 𝑝 = 0.003). Although no association was observed between PD and the risk of cardiac death in patients with CKD (𝑝 = 0.180), while sensitivity analysis revealed PD may be associated with the risk of cardiac death (RR:1.31; 95%CI:1.05-1.64; 𝑝 = 0.017). In addition, subgroup analyses revealed that the strength of the association of PD with the risks of all-cause mortality and cardiac death varies when stratified by region, male proportion, comparison, CKD stage, and adjusted level.ConclusionHerein, PD might exert a harmful effect on the subsequent risks of all-cause mortality and cardiac death in patients with CKD.Copyright © 2024, the Chinese Medical Association.

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