• Yong Zhang, Yanqing Wu, Cuihua Jiang, Ziwei Yang, Xuexue Zhang, Daying Zhang, Fan Yang, and Yi Yan.
• Dept. of Pain Medicine, First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
• Pain Physician. 2024 Sep 1; 27 (7): E775E784E775-E784.

BackgroundTrigeminal herpetic neuralgia (THN) presents with severe pain hyperalgesia and is a high-risk factor for postherpetic neuralgia (PHN). The current clinical treatments for THN are unsatisfactory, and new treatments are desperately required.ObjectivesThis pilot study aimed to evaluate the efficacy of short-term trigeminal ganglion stimulation in treating patients with multi-branch THN.Study DesignA prospective pilot study.SettingMulti-center study in 3 academic hospitals.MethodsFrom July 2021 to October 2022, we enrolled 20 patients with multi-branch THN who received short-term trigeminal ganglion stimulation under general anesthesia from 3 hospitals. All patients completed a 12-month follow-up. The visual analog scale (VAS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess patients' pain and quality of sleep. The Barrow Neurological Institute (BNI) score was used to determine the global outcome of pain relief, and complications were recorded.ResultsSignificant and sustained pain relief and sleep improvement were achieved by all the patients who underwent trigeminal ganglion electrode stimulation in the present study. Respective BNI scores of 80% and 85% at 3 and 12 months after surgery were considered good. There were no other serious complications except for 2 patients' experiences of transient trigeminal cardiac reflex during the surgery and transient numbness deterioration in one patient's V3 sensory area.LimitationsThe present study is a pilot study. We expect prospective multi-center, large-sample studies in the future.ConclusionShort-term trigeminal ganglion stimulation can be used safely and effectively to treat patients with multi-branch THN and significantly reduce the occurrence of PHN.

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