• Rev Med Interne · Nov 2024

    Case Reports

    [An invasive cutaneous aspergillosis during a granulomatosis with polyangiitis].

    • Amir Agade, Cyril Habougit, Cédric Chol, Jean-Baptiste Gaultier, Caroline Mahinc, Lucile Grange, Martin Killian, and Baptiste Gramont.
    • Service de médecine interne, CHU de Saint-Étienne, hôpital Nord, Saint-Étienne, France.
    • Rev Med Interne. 2024 Nov 1; 45 (11): 726730726-730.

    IntroductionAspergillosis is an opportunistic infection that can complicate any situation of immunosuppression. The primary manifestations are pulmonary, and more rarely, in cases of severe immunosuppression, the infection can become invasive with extra-pulmonary involvement.ObservationWe report the case of a 76-year-old female patient, experiencing a relapse of granulomatosis with polyangiitis treated with corticosteroids, rituximab and cyclophosphamide, who presented with diffuse erythematous nodular skin lesions. A biopsy with histological analysis confirmed a diagnosis of invasive cutaneous aspergillosis. Treatment with voriconazole led to a favorable outcome.ConclusionThe appearance of skin lesions in an inflammatory context in a patient receiving immunosuppressive therapy should prompt a comprehensive microbiological assessment for opportunistic pathogens, as well as a skin biopsy to investigate for invasive cutaneous aspergillosis.Copyright © 2024 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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