• Medicina · Jan 2024

    Multicenter Study

    [Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment].

    • Oscar Laudanno, Gabriel Ahumaran, Marcelo Thome, Paola Adami, Fernando Ustares, Oscar Bedini, Javier Bori, Gastón Ahualli, Pablo Rodríguez, Guillermo Fernández, Florencia Dulcich, Gladys Filo, Bianca Laudanno, Marina Khoury, and Registro Argentino Helicobacter Pylori.
    • Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina. E-mail: oscarlaudanno@gmail.com.
    • Medicina (B Aires). 2024 Jan 1; 84 (5): 884892884-892.

    IntroductionThe optimal management of Helicobacter pylori (H pylori) infection remains unclear. Updated information concerning local data is needed to design the best strategy to treat H. pylori infection to reach high eradication rates. The Argentinean Registry (Hp-ArgReg) on H. pylori management was launched to monitor the eradication practices of gastroenterologists. The objective was to assess the effectiveness and safety of firstline H. pylori treatment in Argentina.Materials And MethodsA multicenter prospective registry of the clinical practice of the Argentinean gastroenterologists concerning H. pylori infection (Hp-ArgReg) was developed. Variables included: patient demographic information, previous eradication attempts, prescribed treatment, adverse events, compliance and outcome.ResultsOverall, 800 patients were included and 727 patients received first-line empirical treatment. The most frequent treatment indications were dyspepsia (78%) and gastroduodenal ulcer (12%). Among first-line treatments, quadruple therapies (with or without bismuth) achieved eradication rates of 94.9%, while triple therapies achieved eradication rates of 78.9%. Quadruple therapies were significantly more effective than triple therapies (P < 0.01, OR 5, CI 2.95-8.6). Sequential therapy with zinc showed an effectiveness of 95.6%. Adverse events were reported in 29% of the cases (mainly mild) and tolerance was quite similar among therapies.Conclusionin Argentina, Quadruple therapies with or without bismuth and sequential therapy with zinc showed an H. pylori eradication effectiveness of over 90% in real clinical practice. Local Registries for H pylori management could help to control the spread of antibiotic resistance.

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