• Internal medicine · Oct 2024

    Effectiveness and Safety of Avacopan as a Combination Therapy with Glucocorticoids or Monotherapy in Patients with Microscopic Polyangiitis.

    • Takashi Jubashi, Takuya Tomokawa, Kazusato Hara, Yoshiro Horai, and Atsushi Kawakami.
    • Department of Rheumatology, Sasebo City General Hospital, Japan.
    • Intern. Med. 2024 Oct 11.

    AbstractWe herein report three cases of microscopic polyangiitis (MPA). Two patients were administered avacopan in combination with glucocorticoid (GC), whereas one patient was treated with avacopan monotherapy; none of the patients were co-administered either rituximab or cyclophosphamide. The doses of GC were successfully reduced after the introduction of avacopan in the two patients, and the serum C-reactive protein levels decreased in the patient treated with avacopan monotherapy. Avacopan may therefore be effective either in combination with GC or as monotherapy, even for patients at a high risk of developing adverse effects when administered rituximab or cyclophosphamide.

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