• Aila Malik, Ryan S D'Souza, Jay Karri, and Saba Javed.
• Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX, USA.
• Neuromodulation. 2024 Oct 16.

ObjectivesSympathetically mediated orofacial pain is a rare form of craniofacial pain that may be refractory to conventional medical management. We report two cases of orofacial pain with sympathetic features treated with cervical spinal cord stimulation (SCS) using burst waveform with passive recharge. In addition, we present a narrative review of cervical SCS use in the management of orofacial pain.Materials And MethodsThe MEDLINE (PubMed) data base was queried for studies of orofacial pain and cervical SCS by searching applicable keywords including "face," "facial pain," "trigeminal neuralgia," "complex regional pain syndrome," and "spinal cord stimulation." Studies in the English language published between January 1, 2010 and December 31, 2023 were reviewed for relevance.ResultsOur literature review identified eight studies of cervical SCS use for treating orofacial pain. Our case series and literature review indicate that cervical SCS is probably safe and promising in the treatment of orofacial pain unresponsive to conventional management. Prior studies report positive results in patients with trigeminal nerve-related pain but are retrospective, include a small sample size, and are heterogenous regarding the follow-up period. We report significant analgesia in two patients with sympathetically mediated orofacial pain treated with cervical SCS using burst waveform with passive recharge.ConclusionsCervical SCS is a viable therapeutic option for patients with orofacial pain syndromes including those with sympathetic features, although further randomized clinical studies are warranted that should include a comprehensive set of outcomes measuring pain intensity, physical function, emotional function, quality of life, and general well-being.Copyright © 2024 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.

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