• Bart Gerard Jan Candel, Laura N Visser, Ewoud Ter Avest, Milan L Ridderikhof, Bas De Groot, Rens Jacobs, Saskia Weltings, GroenwoldRolf H HRHHDepartment of Clinical Epidemiology, Leiden University Medical Centre, Leiden, Zuid-Holland, The Netherlands.Department of Biomedical Data sciences, Leiden University Medical Centre, Leiden, Zuid-Holland, The Netherlands., Leti van Bodegom, Wilbert B van den Hout, Marleen Kemper, and Markus W Hollmann.
• Emergency Department, Máxima Medical Centre, Veldhoven, The Netherlands b.candel@mmc.nl.
• Emerg Med J. 2024 Oct 18.

Background And AimThe passage of kidney stones through the ureter creates renal colic, a severe visceral abdominal pain. Renal colic is typically managed with non-steroidal anti-inflammatory drugs and opioids. Yet, these treatments often fail to provide adequate pain relief. The erector spinae plane block (ESPB) has emerged as a potential alternative treatment. This systematic review summarises the current body of evidence on the efficacy and safety of ESPB for renal colic in the ED.MethodsA systematic review and meta-analysis of randomised controlled trials (RCTs) and case series of ESPB in ED patients were conducted. PubMed, EMBASE, Web of Science and ClinicalTrial.gov databases were electronically searched up to 10 June 2024, for studies that compared ESPB with standard care or placebo. The Cochrane risk of bias-2 tool was used to assess the risk of bias of included studies. Meta-analysis using a random effects model was performed if two or more studies reported the same outcome. The Grading of Recommendations Assessment, Development, and Evaluation tool was used to assess the certainty of the evidence.ResultsFour studies were included, including two RCTs and two case series. A total of 53 patients received an ESPB, compared with 40 patients who received standard care. All studies were rated as having a high overall risk of bias. Meta-analysis showed a large and significant effect of ESPB on pain reduction after 30 min (standardised mean difference (SMD) -1.41 95% CI -1.90 to -0.91) and after 60 min (SMD -1.94 95% CI -3.36 to -0.52), however the level of evidence was downgraded to very low certainty due to substantial heterogeneity (I2=85%), serious concerns of bias and large imprecision. Heterogeneity in other outcome measurements precluded meta-analysis.ConclusionsAlthough statistically significant, there is a low certainty regarding the positive effect of ESPB on pain reduction for renal colic in the ED. High-quality RCTs focusing on patient-reported outcomes are needed to establish the merit of ESPB for this indication.Prospero Registration NumberCRD42024554077.© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.

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