• Internal medicine · Oct 2024

    Ovarian Cancer with TTF-1-positive Giant Pleural Dissemination.

    • Kazuo Tsuchiya, Risa Suzuki, Ryota Miyamoto, Tomo Tsunoda, Taisuke Ito, Rie Mori, Takuro Akashi, Yoshiyuki Oyama, and Masaki Ikeda.
    • Department of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
    • Intern. Med. 2024 Oct 18.

    AbstractThyroid transcription factor 1 (TTF-1) is primarily expressed in lung and thyroid cancers, but it has also been observed in other cancers. A 60-year-old woman presented with worsening dyspnea, pleural effusion, lung metastases, a right ovarian tumor, and para-aortic intra-abdominal lymph node metastasis. Biopsies from the pleural dissemination revealed TTF-1-positive adenocarcinomas. To confirm the presence of the primary organ, biopsies were performed on a para-aortic intra-abdominal lymph node that ascended from the ovaries. An adenocarcinoma positive for TTF-1 was identified, thus confirming the diagnosis of ovarian cancer. Our findings revealed that TTF-1 positivity does not always signify a lung cancer origin.

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