• Sao Paulo Med J · Nov 2000

    Case Reports

    Darier's disease: a new paradigm for genetic studies in psychiatric disorders.

    • Q Cordeiro, D M Werebe, and H Vallada.
    • Institute of Psychiatry, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
    • Sao Paulo Med J. 2000 Nov 9; 118 (6): 201203201-3.

    ContextOne strategy for identifying susceptibility genes for common disorders is to investigate Mendelian diseases, cosegregating with these common disease phenotypes.Case ReportA family with seven members is described, in which three members present Darier's disease and depression. This apparent cosegregation, if true, would support the hypothesis that in some pedigrees, a gene for mood disorder may be located on chromosome 12.

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