• Márcia Maria Auxiliadora de Aquino and José Guilherme Cecatti.
• Maternity Hospital Leonor Mendes de Barros, São Paulo, Brazil. mmaa@visualbyte.com.br
• Sao Paulo Med J. 2003 May 5; 121 (3): 102106102-6.

ContextMisoprostol, a synthetic E1 methyl analog prostaglandin, is at present receiving attention as a cervical modifier and labor induction agent. However, there is still a need for better determination of its safety and effectiveness.ObjectiveTo compare intravaginal misoprostol versus intravenous oxytocin for cervical ripening and labor induction in pregnant women with unripe cervices.DesignRandomized controlled trial.SettingThe study was performed at the Leonor Mendes de Barros Maternity Hospital between November 1998 and December 2000.Participants210 pregnant women with intact membranes and indication for labor induction were selected.ProceduresThe women randomly received 25 g of vaginal misoprostol every 4 hours, not exceeding 8 doses (105 women), or oxytocin in a continuous infusion (105 women).Main MeasurementsThe main parameters measured were: latent period, time from induction to vaginal delivery, delivery route, occurrence of vaginal delivery with time, occurrence of uterine tonus alterations, hypoxia and neonatal morbidity. To verify the statistical significance of the differences between the groups, the chi-squared, Student t and log-rank tests were used.ResultsThere were no significant differences between the groups concerning conditions for labor induction, age, parity, race, marital status, family income, initial Bishop Index and number of prenatal visits. The cesarean section rate, latent period and period from induction to vaginal delivery were significantly lower for the misoprostol group. With regard to uterine tonus alterations, tachysystole was significantly more common in the misoprostol group. However, there was no difference in hypoxia and neonatal morbidity between the groups.Conclusion25 g of misoprostol used vaginally every 4 hours is safer and more efficient for cervical ripening and labor induction than oxytocin.

19 keywords...

hide…