• Mehmet Armagan Osmanagaoglu, Selen Osmanagaoglu, Hülya Ulusoy, and Hasan Bozkaya.
• Department of Obstetrics and Gynecology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. osmanaga@meds.ktu.edu.tr
• Sao Paulo Med J. 2006 Mar 2; 124 (2): 858985-9.

Context And ObjectiveDespite the development of tertiary care facilities, intensive care and advanced blood banking techniques, pregnancy-related hypertensive disorders are the main cause of maternal mortality in most countries. Our purpose was to determine maternal outcome in pregnancies complicated by HELLP syndrome (hemolysis, elevated liver enzymes and low platelet count) that required intensive care management.Design And SettingRetrospective study at Department of Obstetrics and Gynecology, and Department of Anesthesiology and Reanimation, Karadeniz Technical University, Trabzon, Turkey.Methods37 patients with HELLP syndrome admitted to the obstetric intensive care unit were analyzed retrospectively from 1992 to 2004.ResultsAll patients were hypertensive, with mean Glasgow coma score (GCS) of 11 +/- 3.96. Mean gestational age at delivery was 32 +/- 4.09 weeks. Delivery was vaginally in nine and by cesarean section in 27 patients. General anesthesia was used in 12 and spinal anesthesia in 25 patients. Maternal morbidity included acute renal failure (11%), disseminated intravascular coagulation (5%), acute lung edema (3%), severe ascites (11%), pleural effusion (3%), adult respiratory distress syndrome (11%), abruptio placenta (11%), cerebral edema (8%) and cerebral hemorrhage (40%). All patients required transfusions using blood products. There were 11 maternal deaths (30%).ConclusionBecause of high maternal mortality and morbidity found among patients with HELLP syndrome, standard antenatal follow-up protocols should be applied, so as to obtain early diagnosis and improve the speed of transfer to obstetric departments with expertise in this field.

17 keywords...

hide…