• Sao Paulo Med J · May 2006

    Case Reports

    Pure sarcomatous recurrence of clear cell renal carcinoma following radical nephrectomy and dendritic cell vaccination.

    • Alberto Azoubel Antunes, Marcos Francisco Dall'Oglio, José Alexandre Marzagão Barbuto, Kátia Ramos Moreira Leite, and Miguel Srougi.
    • Division of Urology, Faculdade de Medicina da Universidade de São Paulo, and Hospital Sírio-Libanês, São Paulo, Brazil.
    • Sao Paulo Med J. 2006 May 4; 124 (3): 161162161-2.

    ContextSarcomatous differentiation, which represents transformation to high-grade malignancy, can occur in all histological types of renal malignancy.Case ReportThe authors report on the case of a 66-year-old woman with a right renal mass that was shown to be a clear cell carcinoma. She underwent radical nephrectomy and dendritic cell vaccination and, 3.5 years later, she developed retroperitoneal pure sarcomatous recurrence of the tumor. The authors speculate that the vaccination could have played some role in this differentiation or selection of the sarcomatous component of the primary tumor.

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