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- M S Rossini, I Lorand-Metze, G B Oliveira, and C A Souza.
- Hematology and Blood Transfusion Center, State University of Campinas, Campinas, Brazil.
- Sao Paulo Med J. 2000 Sep 7; 118 (5): 154157154-7.
ContextLiver damage is relatively common in patients affected by Hodgkin's disease. A smaller proportion of cases develops jaundice. Recently, the vanishing bile duct syndrome was described in Hodgkin's disease. The mechanisms of this severe complication have been poorly understood until now.ObjectiveTo describe a rare case of intra-hepatic cholestasis due to vanishing bile duct syndrome.DesignCase report.Case ReportA 38-year-old male patient affected by Hodgkin's disease. Liver biopsy showed no detectable Hodgkin's disease. Intra-hepatic cholestasis was found and none of the six portal tracts analyzed contained normal bile ducts. The treatment was based on conventional and high-dose escalation chemotherapy. The patient died from an irreversible liver failure while in complete remission from Hodgkin's disease.
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