• Kristin Hofsø, Christine Miaskowski, Kristin Bjordal, Bruce A Cooper, and Tone Rustøen.
• Centre for Shared Decision Making and Nursing Research, Oslo University Hospital, Rikshospitalet, Norway. kristin.hofso@rr-research.no
• Cancer Nurs. 2012 May 1;35(3):167-77.

BackgroundRecent evidence suggests that women who receive treatment for breast cancer may experience multiple symptoms that decrease their functional status and quality of life. Few studies evaluated the occurrence, severity, and distress of multiple symptoms in women at the initiation of radiation therapy (RT) for breast cancer.ObjectiveThis study evaluated for differences in symptoms occurrence, severity, and distress between women with breast cancer who did and did not receive chemotherapy (CTX) prior to RT.MethodsPrior to the initiation of RT, patients completed the Memorial Symptom Assessment Scale (MSAS) that evaluated multiple dimensions of 32 symptoms. Differences in occurrence, severity, and distress scores between the 2 CTX groups were evaluated using χ and Mann-Whitney U tests.ResultsThe 5 symptoms with the highest occurrence rates were lack of energy, worrying, difficulty sleeping, feeling drowsy, sweats, and pain. Women who received CTX prior to RT experienced twice as many symptoms as women who did not receive CTX. Except from difficulty sleeping, the 5 most prevalent symptoms were not the most severe or distressing. A poorer functional status, a higher comorbidity score, and previous CTX were all predictors of a higher number of symptoms.ConclusionsWomen with breast cancer experience large numbers of symptoms at the initiation of RT. Previous CTX doubles the number of symptoms that women report.Implications For PracticeFindings suggest that clinicians need to use a multidimensional symptom assessment tool in women with breast cancer at the initiation of RT.

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