• Casandra Jara, Carlos Veas, Carolina Delgado, Claudia Cabezas, and Mauricio Chandía.
• Unidad de Anatomía Patológica, Hospital Guillermo Grant Benavente, Concepción, Chile.
• Rev Med Chil. 2024 Apr 1; 152 (4): 454459454-459.

UnlabelledCerebrospinal fluid (CSF) involvement in B cell non-Hodgkin lymphomas is a poor prognostic sign and diagnosis is made using techniques such as flow cytometry (FCM) and conventional cytology (CC).AimTo evaluate the frequency of CSF involvement in B-NHL by both techniques in a public hospital.Material And Methods97 CSF samples were analyzed in tubes with cell preservative belonging to 70 patients, 71% male, median age 56 years (18-85 years), with a diagnosis of B-NHL and risk of infiltration according to medical criteria. Most were patients from new diagnosis (89%), diffuse large B cell lymphoma (60%), and Ann-Arbor stage III-IV (77%). In 67 samples (69%), CC and CMF were performed simultaneously.ResultsOf the samples analyzed by CMF, 99% were valuable, while by CC, only 67% (p<0,05). Globally, 25% of the samples showed infiltration by CMF, while 18% by CC (p<0,0001). Forty-four valuable samples were evaluable and analyzed by CC and CMF, finding a similar frequency of positive cases (27%), with two-thirds positive only by CC or CMF. Positive samples in diffuse large B cell lymphoma were 28% by CC and/or CMF.ConclusionsA higher proportion of infiltration cases were detected by CMF than by CC. In valuable cases, CC complements CMF.

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