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Revista médica de Chile · Apr 2024
Review Case Reports[Transformation of Follicular Lymphoma into Composite Lymphoma: A Case Report and Literature Review].
- Alejandro Avilés-Salas, Laura Felisa Peña-Carvajalino, Andrea Nallely Heredia-Jara, José Ángel Arriaga-Marroquín, and Myrna Candelaria.
- Departamento de Patología, Instituto Nacional de Cancerología, México.
- Rev Med Chil. 2024 Apr 1; 152 (4): 508513508-513.
AbstractFollicular lymphoma is a relatively indolent B-cell lymphoma composed of neoplastic centrocytes and centroblasts. The histologic transformation of follicular lymphoma is a well-described phenomenon with an average risk of 30% at ten years. The occurrence of Hodgkin lymphoma after follicular lymphoma, as well as composite lymphoma, is extremely rare. We report the case of a 79-year-old man with generalized lymphadenopathy who was diagnosed with follicular lymphoma and treated with six cycles of R-CHOP with a complete response. A lymph node biopsy three years later revealed persistent follicular lymphoma, after which the patient received radiotherapy. The patient returned with progressively enlarging axillary lymph nodes five years later. A lymph node biopsy demonstrated a composite lymphoma that was consistent with follicular lymphoma and Hodgkin lymphoma.
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