• Internal medicine · Oct 2024

    Hidden MODY in Young Lean Women with Mild Glucose Intolerance Detected During Health Check-ups: Potential for Improved Pregnancy Outcomes Through Preconception Care.

    • Aya Osaki, Atsushi Ozawa, Akihito Morita, Daisuke Higeta, Sunpei Suda, Yoshiaki Ohtsu, Satoshi Yoshino, Syunichi Matsumoto, Kazuhiko Horiguchi, and Eijiro Yamada.
    • Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Japan.
    • Intern. Med. 2024 Oct 25.

    AbstractMild glucose intolerance (positive urine glucose or mild hyperglycemia) during health checkups in young, lean women may require specialist consultation. We herein report a 31-year-old Japanese woman with mild hyperglycemia detected during a checkup who was diagnosed with overt diabetes in pregnancy and HNF4A-MODY postpartum, without prior follow-up. This case highlights the following: MODY may be present in young, lean women with mild glucose intolerance, and preconception care may improve pregnancy outcomes. Fetal outcomes vary with MODY subtype. Preconception care is important.

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