• Christian Banciu, Sorin Chiriac, Cristina Pojoga, Loredana Marian, Antonio Fabian, Armand Gogulescu, Mihaela Simu, Ramona Parvanescu, Alexandra Mioc, Roxana Racoviceanu, and Andreea Munteanu.
• Department of Internal Medicine IV, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
• Medicina (Kaunas). 2024 Oct 17; 60 (10).

AbstractThis case report describes an uncommon overlap syndrome between ankylosing spondylitis (AS) and amyotrophic lateral sclerosis (ALS). Initially, the patient was diagnosed with AS, for which he received various specific treatments, including TNF-α inhibitors. After five years of treatment with TNF-α inhibitor etanercept, the patient was referred for a full neurological assessment after he reported balance disturbances, postural instability, muscle weakness, and other neurological symptoms that indicated the presence of a neurological disorder. After a thorough investigation, the patient was diagnosed with ALS. This case report aims to contribute to the limited literature by providing a detailed case study regarding the crosstalk between AS and ALS while also exploring the potential underlying mechanisms and the possible link between TNF-α inhibitors therapy and ALS.

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