• Zeliha Güzelküçük, Dilek Gürlek Gökçebay, Turan Bayhan, İkbal Ok Bozkaya, Özlem Arman Bilir, Vildan Koşan Çulha, Melek Işik, Ayca Koca Yozgat, Hüsniye Neşe Yarali, and Namık Yaşar Özbek.
• Department of Pediatrics, Division of Pediatric Hematology Oncology, Ankara Bilkent City Hospital, Ankara, Turkiye.
• Turk J Med Sci. 2024 Jan 1; 54 (5): 924929924-929.

Background/AimThe transfusion of blood products is a life-saving clinical practice in patients with bleeding, hemoglobinopathy, and cancer. It was aimed herein to analyze the frequency and types of blood component-related acute transfusion reactions (ATRs) in pediatric patients.Materials And MethodsThis retrospective study was conducted at a tertiary care academic pediatric hospital.ResultsDuring the study period, 30,811 transfusions were administered to 25,448 patients. There were 103 ATRs detected in 81 patients (0.33%; 3.34 reactions per 1000 transfusions, mean age 8.3 ± 5.98 years, 36 females and 45 males). All the reactions were observed within an average of 4 h after the transfusion began. The most common ATRs were allergic reactions (79; 76.6%) and febrile nonhemolytic transfusion reactions (12; 11.6%). All the allergic transfusion reactions occurred within the first hour after the start of the transfusion. Granulocyte concentrates were the blood component associated with the highest ATR rate (2.1%).ConclusionWithin our hospital, pediatric hematology-oncology wards and the stem cell transplantation unit had the most frequent ATR reports; therefore, when transfusions are carried out, increased attention should be given to these units. Educating health staff about the adverse effects of transfusion therapy should increase the awareness and reporting of ATRs in children.© TÜBİTAK.

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