First-line therapy for high-risk people with chronic

Cochrane Db Syst Rev · Oct 2024

Meta Analysis

First-line therapy for high-risk people with chronic lymphocytic leukemia: a network meta-analysis.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective: to assess the benefits and harms of currently recommended regimens as the first-line therapy in high-risk people with chronic lymphocytic leukemia, using network meta-analysis Secondary objectives: to assess whether the benefits and harms of the recommended regimens differ according to sex, Rai stage, or genetic mutation status to estimate the ranking of treatments for overall survival, progression-free survival, objective response rate, complete response rate, minimal residual disease, and serious adverse events to estimate the overall rate of adverse events and serious adverse events.

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- Kenichi Miyamoto, Akihiro Ohmoto, Daisuke Yoneoka, Md Obaidur Rahman, and Erika Ota.
- Department of Health Policy and Informatics, Graduate School of Medicine, Institute of Science Tokyo, Tokyo, Japan.
- Cochrane Db Syst Rev. 2024 Oct 30; 10 (10): CD015169CD015169.
AbstractThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective: to assess the benefits and harms of currently recommended regimens as the first-line therapy in high-risk people with chronic lymphocytic leukemia, using network meta-analysis Secondary objectives: to assess whether the benefits and harms of the recommended regimens differ according to sex, Rai stage, or genetic mutation status to estimate the ranking of treatments for overall survival, progression-free survival, objective response rate, complete response rate, minimal residual disease, and serious adverse events to estimate the overall rate of adverse events and serious adverse events.Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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First-line therapy for high-risk people with chronic lymphocytic leukemia: a network meta-analysis.

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