• Curr Pain Headache Rep · Nov 2024

    Review

    An Update on Emerging Regenerative Medicine Applications: The Use of Extracellular Vesicles and Exosomes for the Management of Chronic Pain.

    • William D Shipman, Raquel Fonseca, Moises Dominguez, Sadiq Bhayani, Christopher Gilligan, Sudhir Diwan, David Rosenblum, Sait Ashina, Reda Tolba, Alaa Abd-Elsayed, Alan D Kaye, Jamal Hasoon, Michael E Schatman, Timothy Deer, Jason Yong, and Christopher L Robinson.
    • Department of Dermatology, Yale University School of Medicine, 333 Cedar Street, LMP 5040, Box 208059, New Haven, CT, 06520, USA. wdshipman@gmail.com.
    • Curr Pain Headache Rep. 2024 Nov 4.

    Purpose Of ReviewChronic pain affects nearly two billion people worldwide, surpassing heart disease, diabetes, and cancer in terms of economic costs. Lower back pain alone is the leading cause of years lived with disability worldwide. Despite limited treatment options, regenerative medicine, particularly extracellular vesicles (EVs) and exosomes, holds early promise for patients who have exhausted other treatment options. EVs, including exosomes, are nano-sized structures released by cells, facilitating cellular communication through bioactive molecule transfer, and offering potential regenerative properties to damaged tissues. Here, we review the potential of EVs and exosomes for the management of chronic pain.Recent FindingsIn osteoarthritis, various exosomes, such as those derived from synovial mesenchymal stem cells, human placental cells, dental pulp stem cells, and bone marrow-derived mesenchymal stem cells (MSCs), demonstrate the ability to reduce inflammation, promote tissue repair, and alleviate pain in animal models. In intervertebral disc disease, Wharton's jelly MSC-derived EVs enhance cell viability and reduce inflammation. In addition, various forms of exosomes have been shown to reduce signs of inflammation in neurons and alleviate pain in neuropathic conditions in animal models. Although clinical applications of EVs and exosomes are still in the early clinical stages, they offer immense potential in the future management of chronic pain conditions. Clinical trials are ongoing to explore their therapeutic potential further, and with more research the potential applicability of EVs and exosomes will be fully understood.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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