• Liji Chen, Cailing Zhong, Longxiu Fan, Ming Luo, Linkun Cai, Beiping Zhang, and Haiyan Zhang.
• The Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
• Medicine (Baltimore). 2024 Nov 1; 103 (44): e40370e40370.

RationaleThis article presents a complex case of refractory Henoch-Schönlein purpura (HSP), initially manifesting with complex gastrointestinal (GI) symptoms, and discusses diagnostic and therapeutic challenges encountered. It aims to enhance understanding of the disease and provide evidence for the potential efficacy of intravenous immunoglobulin (IVIG) treatment in this condition.Patient ConcernsA 16-year-old male patient presented with persistent abdominal pain, nausea, vomiting, and constipation for 8 days, leading to hospital admission.DiagnosesEstablishing a definitive diagnosis was challenging initially due to the absence of typical petechiae. However, the appearance of characteristic petechiae subsequently confirmed the diagnosis of HSP.InterventionsInitial treatment with methylprednisolone sodium succinate for 3 days failed to elicit improvement. Subsequently, IVIG was introduced as a combination therapy.OutcomesFollowing the combined administration of IVIG, the patient experienced complete resolution of abdominal pain, petechiae, and arthralgia within 4 days.LessonsThis case highlights the importance of considering HSP in the differential diagnosis of patients with complex GI symptoms. Furthermore, it suggests that IVIG may be a valuable therapeutic option for HSP patients with refractory GI symptoms. High-quality comparative trials are needed to establish more definitive evidence for the effectiveness of IVIG and to develop specific treatment guidelines.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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