• Emmanuel Ifeanyi Obeagu, Getrude Uzoma Obeagu, and Callistus Adewale Akinleye.
• Department of Medical Laboratory Science, Kampala International University, Kampala, Uganda.
• Medicine (Baltimore). 2024 Nov 1; 103 (44): e40384e40384.

AbstractThe intricate interplay between the human immunodeficiency virus (HIV) and the immune system has long been a focal point in understanding disease progression. Among the myriad of immune cells, basophils, often overshadowed, have recently emerged as pivotal contributors to the complex immunological landscape of HIV infection. This paper aims to provide a succinct overview of the enigmatic roles of basophils in HIV pathogenesis, elucidating their multifaceted functions and implications. Basophils, conventionally perceived as minor players in immune responses, exhibit active participation in HIV infection. Their activation triggered by viral antigens, cytokines, and immune complexes orchestrates a cascade of immune events, influencing immune modulation, cytokine release, and the activation of adaptive immune cells. Furthermore, basophils function as antigen-presenting cells, potentially impacting viral dissemination and immune dysregulation. Additionally, basophils serve as crucial regulators in HIV infection through cytokine secretion, notably interleukin (IL)-4, IL-13, and IL-3, influencing immune cell differentiation, polarization, and antibody production. Their interactions with various immune cells intricately shape the immune response against HIV, impacting disease progression and immune equilibrium. Moreover, harnessing basophils as potential vaccine targets or immune modulators represents a compelling avenue for future research. In conclusion, the emerging understanding of basophils' multifaceted involvement in HIV infection challenges prior perceptions and underscores their significance in shaping immune responses and disease outcomes. This abstraction highlights the need for continued research to unlock the full potential of basophils, paving the way for novel strategies in combatting HIV/AIDS.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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