• Fillip Ferreira Eikeseth, Geir Pedersen, Benjamin Hummelen, Stefan Sütterlin, Audun Stubhaug, Elfrida Hartveit Kvarstein, and Gunnvald Kvarstein.
• Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital, Norway; Institute of Clinical Medicine, University of Oslo, Norway. Electronic address: f.f.eikeseth@studmed.uio.no.
• J Pain. 2024 Oct 30; 26: 104724104724.

AbstractPersonality disorders (PDs) are prevalent among individuals with chronic pain, but less is known about the prevalence of pain in the PD population. This study therefore sought to explore the prevalence of current or everyday pain among individuals referred to outpatient PD treatment, and further explore the mediating role of negative affect in the relationship between PD severity and current pain. Data was retrieved from the Norwegian Network for PDs' quality register which included 4361 participants. Pain was operationalized using the EQ-5D-3L "pain or discomfort" item and four SCL-90-R pain-related items ("pain bothersomeness"). Rates of self-reported pain were explored both pre and post treatment to determine the persistency of the pain-related symptoms. The role of negative affect in the relationship between PD severity and pain was investigated by linear regression analysis. A substantial burden of pain-related symptoms was demonstrated, as 71 % and 80 % reported moderate to extreme pain or discomfort and pain bothersomeness, respectively. Muscle soreness was the most common pain (59 %) followed by headache (48 %), low back pain (46 %), and heart or chest pain (34 %). Moderate to extreme pain or discomfort was persistent for 77 % of the participants who provided end of treatment data (mean treatment duration was 82 weeks). Negative affect mediated the relationship between PD severity and pain. To our knowledge, this is the first large-scale study on everyday pain in patients with PDs. The findings reveal that moderate to extreme pain is prevalent among persons with PDs and that this co-occurrence is driven by negative affect. PERSPECTIVE: Pain is a prevalent and potentially underrecognized symptom in personality disorders and persists until treatment termination for a large group of patients. This co-occurrence may be driven by a susceptibility to negative affect that is enhanced by personality disorder features.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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