• Emmanuele Santolini, Vincenzo Giordano, and Peter V Giannoudis.
• Orthopaedics and Trauma Unit, Emergency Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
• Injury. 2024 Nov 1; 55 Suppl 6: 111845111845.

AbstractFracture related infection (FRI) remains one of the most challenging complications of orthopaedic trauma surgery. Several factors contribute to FRI development but, among those, particularly interesting from the orthopaedic surgeon's perspective is the contribution of mechanical stability and timing of fracture fixation. These are indeed crucial factors both in prevention and treatment of FRI and are directly influenced by the surgeon's work. While the role of stability has been studied and discussed, the pathophysiological process regulating such role and how this influences surgeon's treatment decision making is still debated. The same applies to the ideal timing of temporary or definitive fixation which varies according to the clinical scenario considered. In the present narrative review, we described the influence of mechanical stability on both FRI pathophysiology and on the decision making of FRI treatment. In addition, we analysed the impact of the timing of fracture fixation on the risk of FRI development particularly in those clinical scenarios where it has been shown to be specifically relevant, such as fractures affecting segments with poor soft tissue envelope, open fractures, damage control orthopaedics, and the need for soft tissue coverage.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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