• Ada Hoffmann, Jörgen Hoffmann, Tamara Ruegamer, Norma Jung, Ronald Man Yeung Wong, Volker Alt, Peer Eysel, and Jonathan Jantsch.
• Institute for Medical Microbiology, Immunology, and Hygiene, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.
• Injury. 2024 Nov 1; 55 Suppl 6: 111898111898.

AbstractThe diagnosis of fracture-related infections (FRI) is challenging and requires interdisciplinary efforts. Many diagnostic approaches are based on the algorithms established for prosthetic joint infections (PJI). Data specific to FRI are limited. Microbiological diagnostics include tissue culture, sonication, and molecular methods. Novel metagenomic analyses are increasingly being used in clinical diagnostic practice. In addition to bacterial detection, the study of host tissue factors has the potential to transform the diagnostics of FRI by facilitating the assesment of clinical significance in clinical samples. The integration of host tissue analysis into microbiology reports has great potential to improve the diagnosis of FRI. This mini-review describes the potential improvement of diagnostic techniques by integrating new approaches into the diagnostic algorithm of fracture-related infections.Copyright © 2024. Published by Elsevier Ltd.

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