• Bratisl Med J · Jan 2024

    Review

    Mitochondrial oxidative stress in immunopathogenesis of diseases.

    • Juraj Deglovic, Marek Supler, Mario Dvorzak, and Katarina Gazdikova.
    • Bratisl Med J. 2024 Jan 1; 125 (11): 706712706-712.

    AbstractMitochondria are subcellular organelles involved in many metabolic events, including oxidative phosphorylation and signaling in tissue-specific processes. They play a key role in cell proliferation, differentiation and death.Diseases in the pathogenesis of which mitochondrial oxidative stress and immunity play a significant role include cancer, cardiovascular, nervous and rheumatic diseases as well as liver, lung and kidney diseases. In addition, mitochondria participate in the pathogenesis of infections and autoimmunity.Mitochondrial dysfunction can be positively influenced by administration of antioxidants, including coenzyme Q10 (Tab. 1, Fig. 5, Ref. 20). Text in PDF www.elis.sk Keywords: mitochondria, immunopathogenesis, bronchial asthma, chronic hepatitis C, reactive oxidative species, antioxidants, coenzyme Q10.

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