• Andrés Pérez Hurtado, Isabel Martínez Cordellat, Roxana González Mazario, Elena Grau García, and Román IvorraJosé AndrésJAServicio de Reumatología, Hospital Universitario y Politécnico La Fe, Valencia, España..
• Servicio de Reumatología, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address: perez_andhur@gva.es.
• Med Clin (Barc). 2024 Nov 7.

Background And ObjectivesRhupus is a very rare syndrome of overlapping rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), characterized by the presence of erosive polyarthritis associated with symptoms and signs of SLE and the presence of high specificity autoantibodies. The analysis of HLA-DR molecules would allow us to genetically characterize patients diagnosed with rhupus, being able to differentiate them from the HLA-DR profile of patients with RA and SLE.Materials And MethodsCross-sectional observational study of 9 patients diagnosed with rhupus in whom the HLA-DR genotype was genetically characterized.ResultsRhupus is usually more frequent in women with initial diagnosis of RA. The most frequent clinical manifestations are articular and, serologically, ANA, RF and anti-CCP positivity stand out. The most frequent HLA-DR were HLA-DR1, HLA-DR3, HLA-DR4, HLA-DR7 and HLA-DR13.ConclusionsA higher proportion of HLA-DR1 and DR9 was observed in patients with rhupus compared to RA and SLE, as well as a lower proportion of HLA-DR2, DR6 and DR8, which would help the early characterization of these patients prior to the overlap diagnosis.Copyright © 2024 Elsevier España, S.L.U. All rights reserved.

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