• Sao Paulo Med J · Sep 2009

    Case Reports

    Primary malignancy in giant cell tumor: a case report.

    • Rosalvo Zósimo Bispo Júnior, CamargoOlavo Pires deOP, Cristiane Marie Ida, André Mathias Baptista, Marcelo Barbosa Ribeiro, José Marcello Bruno, and Cláudia Regina Gomes Cardim Mendes de Oliveira.
    • Department of Orthopedics and Traumatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. zosimo_jr@yahoo.com.br
    • Sao Paulo Med J. 2009 Sep 1; 127 (5): 310313310-3.

    ContextPrimary malignancy in giant cell tumor (PMGCT) is rare. It is defined as a high-grade sarcoma originating in a giant cell tumor (GCT) and seems to behave less aggressively than its secondary counterpart does.Case ReportThis report presents the case of a 39-year-old female with pain in her left shoulder for one month. Radiography showed a pathological fracture of the proximal humerus associated with an osteolytic lesion. Histopathological analysis showed typical areas of GCT juxtaposed with a sarcomatous component.ConclusionsPMGCT seems to behave less aggressively than secondary malignancy in GCT, and it may simulate its more common benign counterpart clinically and radiographically. However, it requires a more aggressive type of treatment.

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