• Chest · Nov 2024

    Case Reports

    Diffuse Alveolar Hemorrhage Due to Bupropion Inhalation.

    • Zachary Kuschner, Christina Gearges, Zahra Asghar, Junaid Anwar, and Glen Granati.
    • Mather Hospital at Northwell, Port Jefferson, NY. Electronic address: Zachary.kuschner@NYCHHC.org.
    • Chest. 2024 Nov 1; 166 (5): e133e135e133-e135.

    AbstractDiffuse alveolar hemorrhage (DAH) is a form of hemoptysis caused by disruption of the alveolar-capillary basement membrane causing alveolar bleeding. Inhalation of cocaine and other sympathomimetic agents are described as one of many pathologic causes. We describe what is to the author's knowledge the first reported case of DAH caused by inhalation of bupropion, a norepinephrine-dopamine reuptake inhibitor, which was successfully treated with systemic steroids. This case adds a novel agent to the known pathologic causes of DAH and introduces a novel form of bupropion toxicity, which should be considered as a cause in cases of DAH in the appropriate clinical context. The case also highlights the potential for further research into the pathologic interactions of bupropion at the alveolar basement membrane.Copyright © 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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