• Milos Stulic, Djordje Culafic, Radmila Obrenovic, Goran Jankovic, Tamara Alempijevic, LalosevicMilica StojkovicMSClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia. jagodica85@gmail.com., Natasa Dostanic, Sandra Vezmar Kovacevic, and Milica Culafic.
• Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia. drstulic@gmail.com.
• Medicina (Kaunas). 2018 May 28; 54 (3).

BackgroundData suggest cystatin C (CysC) levels and hepatic artery resistive index (HARI) correspond to the progression of chronic liver disease. We aimed to evaluate the clinical significance of these parameters in assessment of fibrosis in patients with liver cirrhosis.MethodsThe cross-sectional study included 63 patients with liver cirrhosis. A control group consisted of 30 age- and gender-matched healthy persons.ResultsWe confirmed significantly higher values of CysC in patients with cirrhosis compared to control group (p = 0.036). Average value of HARI in the examined group was increased (0.72 ± 0.06) and there was the statistically significant difference compared to controls (0.66 ± 0.03) (p < 0.001). We found statistically significant correlation between HARI and CysC in the study group. Analyzing the possibility of distinguishing healthy subjects from patients with fibrosis, we have found that the area under the curve is far greater in the HARI index than CysC. Comparison of CysC among Child⁻Pugh stages and correlation with a model for end-stage liver disease (MELD) score showed statistically significant results.ConclusionWe confirmed HARI is a more accurate parameter than CysC in discriminating healthy subjects from patients with fibrosis, while CysC could be a better indicator of the stage of liver cirrhosis.

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