Utility of Lactate Levels in the Diagnosis and Prognosis of

Pediatric emergency care · Oct 2024

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Utility of Lactate Levels in the Diagnosis and Prognosis of Septic Shock.

Early recognition of septic shock and its treatment are key factors for limiting progression to multiple organ dysfunction and death. Lactate, a byproduct of metabolic pathways, is usually elevated in tissue hypoperfusion and shock and is associated with poor prognosis in sepsis. As a biomarker, it may help the clinician in risk stratification, and the identification and treatment of sepsis. In this article, we provide an update on lactate's pathophysiology and role in diagnosis, treatment, and prognosis in children with sepsis and septic shock.

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- Daniela Carla de Souza, Roberto Jabornisky, and Niranjan Kissoon.
- From the Professor, Department of Pediatrics, Pediatric Intensive Care Unit, Hospital Universitário da Universidade de Sao Paulo, São Paulo, Brazil; Chair Latin American Sepsis Institute, Brazil.
- Pediatr Emerg Care. 2024 Oct 1; 40 (10): 736745736-745.
AbstractEarly recognition of septic shock and its treatment are key factors for limiting progression to multiple organ dysfunction and death. Lactate, a byproduct of metabolic pathways, is usually elevated in tissue hypoperfusion and shock and is associated with poor prognosis in sepsis. As a biomarker, it may help the clinician in risk stratification, and the identification and treatment of sepsis. In this article, we provide an update on lactate's pathophysiology and role in diagnosis, treatment, and prognosis in children with sepsis and septic shock.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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Utility of Lactate Levels in the Diagnosis and Prognosis of Septic Shock.

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