• Da Ni.
• Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
• Medicine (Baltimore). 2024 Nov 8; 103 (45): e40553e40553.

AbstractThis review aims to provide a recent update on the Hippo pathway in oral diseases. The Hippo pathway plays a crucial role in organ development, tissue regeneration, wound healing, maintaining epithelial homeostasis, and modulating the immune system. Globally, billions of people suffer from various oral diseases, posing significant public health risks and resulting in substantial economic losses. This article reviews the recent advancements in the research on the Hippo signaling pathway and its effectors in various conditions related to oral health. The implications of Hippo signaling in various dental fields, including endodontics, orthodontics, periodontology, oral implantology, oral and maxillofacial surgery, and oncology are discussed. It provides readers with an overview of the regulatory role of the Hippo pathway in the development of various oral diseases and the potential for exploiting this pathway for developing targeted therapeutics.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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