• Qihang Sun, Qingshun Zhu, Xuren Lu, Guangxu Zhu, Wei Lang, Jie Zhang, and Jianjun Qu.
• General Surgery Department, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
• Medicine (Baltimore). 2024 Nov 8; 103 (45): e40434e40434.

RationaleSchwannomas are common peripheral nerve tumors originating from Schwann cells, primarily occurring in the head and neck, limbs, and trunk. Schwannomas occurring in the mesocolon are rare and often have no specific manifestations. Abdominal schwannomas need to be differentiated from common abdominal tumors such as gastrointestinal stromal tumors.Patient ConcernsWe report a case of a mesocolic schwannoma in a 59-year-old female presenting with gastrointestinal symptoms of acid reflux. At an outside hospital, gastroscopy, colonoscopy, and abdominal computed tomography scans revealed a soft tissue mass adjacent to the greater curvature of the stomach, leading to a suspicion of a gastric mesenchymal tumor.DiagnosesMesocolic schwannoma.InterventionsLaparoscopy was performed at our hospital. Intraoperatively, the tumor was found to be closely related to the transverse colon and was initially diagnosed as a mass originating from the transverse colon. Consequently, a resection of the mass along with the adherent portion of the transverse colon was performed. Postoperative pathology and immunohistochemistry confirmed that the tumor was a schwannoma of the mesentery and did not originate from the transverse colon.Outcomes And LessonsSchwannomas can be distinguished from gastrointestinal stromal tumors by immunohistochemical staining, and surgical treatment is effective for benign schwannomas.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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