• Serbulent Yigit, Ayse Feyda Nursal, Atac Celik, Recai Aci, and Elgiz Askeroglu.
• Ondokuz Mayıs University, Faculty of Veterinary Medicine, Department of Genetics - Samsun, Turkey.
• Rev Assoc Med Bras (1992). 2024 Jan 1; 70 (10): e20240333e20240333.

ObjectiveCoronary artery disease is the leading cause of death worldwide. Vascular endothelial growth factor is known to induce endothelial cell migration and proliferation, increase vascular permeability, and modulate thrombogenicity. The aim of this study is to investigate the relationship between the VEGF insertion/deletion (I/D) variant (rs35569394) and coronary artery disease susceptibility in the Turkish population.MethodsA total of 206 subjects, including 106 coronary artery disease patients and 100 controls, were included in this study. The VEGF I/D variant was genotyped using the polymerase chain reaction method.ResultsThe frequency of the I/I, I/D, and D/D genotypes was 35.84 versus 37%, 33.97 versus 36%, and 30.19 versus 27% in patients and the control group, respectively. VEGF I/D genotype and allele distribution were not statistically significant between coronary artery disease patients and controls (p>0.05). There was no significant difference between VEGF I/D genotype distribution and patient characteristics including age, gender, disease duration, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, history of hypertension, history of diabetes mellitus, and smoking (p>0.05).ConclusionThis study suggests that the VEGF I/D variant is not a predisposing factor to coronary artery disease disease in a Turkish sample.

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